14 April 2021>: Animal Study
Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling PathwaysJingwen Zhou 1ABCE* , Xiaolong Zhang 1A* , Lingfeng Wan 1AD , Jun Yu 2BCD , Tianci Li 2BCD , Ziyu Lu 3BCD , Nanyuan Fang 1E , Lixia Sun 1AG* , Fang Ye 2AG*
Med Sci Monit 2021; 27:e929438
Figure 4 Effects of Zi Qi decoction on collagen deposition in liver tissue. (A) The effects of Zi Qi decoction on the relative messenger RNA level of Types I and III collagen and α-SMA in liver tissue of hepatic fibrosis rats. (B) The effects of Zi Qi decoction on the protein level of Types I and III collagen and α-SMA in liver tissue in each group. (C) Immunohistochemical staining assay of α-SMA and Type I collagen. Magnification ×200. ### P<0.001, compared with the control group. * P<0.05, ** P<0.01, *** P<0.001, compared with the vehicle group. Data were presented as means±standard deviations.