14 April 2021>: Animal Study
Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling PathwaysJingwen Zhou 1ABCE* , Xiaolong Zhang 1A* , Lingfeng Wan 1AD , Jun Yu 2BCD , Tianci Li 2BCD , Ziyu Lu 3BCD , Nanyuan Fang 1E , Lixia Sun 1AG* , Fang Ye 2AG*
Med Sci Monit 2021; 27:e929438
Figure 1 Zi Qi decoction plays a role in preventing activation of hepatic stellate cells. (A) The effects of Zi Qi decoction on cell viability at different concentrations. (B) The effects of Zi Qi decoction on the relative messenger RNA level of cellular Types I and III collagen and α-SMA at different concentrations. (C) The effects of Zi Qi decoction on the protein level of cellular Types I and III collagen and α-SMA at different concentrations. * P<0.05, ** P<0.01, *** P<0.001, compared with the LPS group. Data were presented as means±standard deviations.