14 July 2021>: Animal StudyJian-Hong Wu 1ABCDEF* , Chun-Fang Lv 1ABDE* , Xu-Jun Guo 1CDEF* , Huan Zhang 2CF , Jinde Zhang 1BD , Yangfeng Xu 1BD , Jian Wang 1AEG** , Sheng-Yuan Liu 1ACEFG***
Med Sci Monit 2021; 27:e929346
Figure 3 (A) Emodin reduced LDL-C concentration in serum and upregulated (B) hepatic LDLR mRNA expression and (C) LDLR protein expression. Hepatic LDLR mRNA and protein levels were determined by RT-qPCR and western blotting, respectively. Data are expressed as mean±SD, n=6–8. HCD – high-cholesterol diet group; SIM – simvastatin (10 mg/kg) treatment group; EH – high-dose emodin (100 mg/kg) treatment group; EM – medium-dose emodin (30 mg/kg) treatment group; EL – low-dose emodin (10 mg/kg) treatment group. # P<0.05, ## P<0.01, ### P<0.001 vs standard diet control group; * P<0.05, ** P<0.01, *** P<0.001 vs untreated HCD group.