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14 July 2021: Animal Study

Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol

Jian-Hong Wu 1ABCDEF* , Chun-Fang Lv 1ABDE* , Xu-Jun Guo 1CDEF* , Huan Zhang 2CF , Jinde Zhang 1BD , Yangfeng Xu 1BD , Jian Wang 1AEG** , Sheng-Yuan Liu 1ACEFG***

DOI: 10.12659/MSM.929346

Med Sci Monit 2021; 27:e929346

Figure 2 Emodin increased nitrate/nitrite production and upregulated aortic eNOS. (A) In vitro nitrate/nitrite production from isolated aortas challenged with acetylcholine (1 μM). (B) Emodin upregulated aortic eNOS mRNA expression and (C) p-eNOS protein expression. Aortic eNOS mRNA and p-eNOS protein levels were determined by RT-qPCR and western blotting, respectively. Data are expressed as means±SD, n=6–8. HCD – high-cholesterol diet group; SIM – simvastatin (10 mg/kg) treatment group; EH – high-dose emodin (100 mg/kg) treatment group; EM – medium-dose emodin (30 mg/kg) treatment group; EL – low-dose emodin (10 mg/kg) treatment group; T-eNOS – total endothelial nitric oxide synthase; p-eNOS – phosphorylated/activated form of eNOS. # P<0.05, ## P<0.01, ### P<0.001 vs standard diet control group; * P<0.05, ** P<0.01, *** P<0.001 vs untreated HCD group.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750