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14 July 2021: Animal Study

Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol

Jian-Hong Wu 1ABCDEF* , Chun-Fang Lv 1ABDE* , Xu-Jun Guo 1CDEF* , Huan Zhang 2CF , Jinde Zhang 1BD , Yangfeng Xu 1BD , Jian Wang 1AEG** , Sheng-Yuan Liu 1ACEFG***

DOI: 10.12659/MSM.929346

Med Sci Monit 2021; 27:e929346

Figure 1 The acetylcholine concentration-response curves of the thoracic aortic rings are presented as decreases in the percentage of the steady-state precontraction tension obtained with 1 μM phenylephrine in (A) control, HCD, and SIM groups and (B) HCD, EH, EM, and EL groups. Data shown are the mean±SD, n=6–8. HCD – high-cholesterol diet group; SIM – simvastatin (10 mg/kg) treatment group; EH – high-dose emodin (100 mg/kg) treatment group; EM – medium-dose emodin (30 mg/kg) treatment group; EL – low-dose emodin (10 mg/kg) treatment group. ## P<0.01 vs control group; ** P<0.01 vs HCD group; NS – not significant.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750