20 April 2021: Clinical Research
Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts
Jiaxin Guan 1BCEF , Lu Gan 1B , Di Jin 1ACD , Xiaowei Wu 1B , Luyang Cheng 1C , Meiling Liu 1C , Ying Fan 1B , Jing Zhou 2B , Hanlu Zhang 1B , Yina Zhang 1AFG* , Ping Zhou 1FG*DOI: 10.12659/MSM.929170
Med Sci Monit 2021; 27:e929170
Figure 3 Tartrate-resistant acid phosphatase (TRAP) staining of osteoclasts in different groups (magnification, ×400). (A) Control group exposed to phosphate-buffered saline (PBS). (B) Cells exposed to receptor activator of nuclear factor (NF)-κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) for osteoclast induction. (C) Empty vector group exposed to RANKL and M-CSF. (D) hsa_circ_0021739 overexpression group exposed to RANKL and M-CSF. (E) Microscopic images showing cell morphology and numbers of TRAP-positive cells. *** P<0.0001.