12 February 2021>: Animal Study
Effects of Betulinic Acid Derivative on Lung Inflammation in a Mouse Model of Chronic Obstructive Pulmonary Disease Induced by Particulate Matter 2.5
Qianyu Yue BCDE , Xiaoli Deng BCD , Yuntao Li BCD , Yunhui Zhang ADEFG*DOI: 10.12659/MSM.928954
Med Sci Monit 2021; 27:e928954
Figure 4 Betulinic acid inhibits PM2.5-mediated production of TNF-α and IL-6 levels in BALF of mice. The PM2.5-exposed mice were treated with 2-, 5-, and 8-mg/kg doses of betulinic acid. The BALF samples were analyzed by (A) western blotting and (B) ELISA assays for TNF-α and IL-6 content. * P<0.05 and ** P<0.02 vs sham group.