03 February 2021: Clinical Research
U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study
Hao You 1ABCE* , Kegong Chen 2BCE* , Pengfei Han 3C , ChaoFu Yue 4B , Xia Zhao 5ADEG*DOI: 10.12659/MSM.928937
Med Sci Monit 2021; 27:e928937
Figure 2 The non-linear associations between uric acid levels and all-cause and cardiovascular mortality. The restricted cubic spline shows the relationship between UA and all-cause (A) and cardiovascular (B) mortality risk. The fitting includes 5 knots: the 5th, 27.5th, 50th, 72.5th, and 95th percentiles. HR (95% CI) was estimated with multivariable Cox regression analysis after adjustment for Model 3. The solid and dashed lines represent point estimates and 95% CIs, respectively. The non-linear trend was significant for the relationship between UA and all-cause and cardiovascular mortality (P for non-linearity ≤0.035).