22 January 2021>: Animal Study
Evaluation of Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft Substitute: An Animal Experimental Study
Zhiqiang Yang ABCDEF , Lingfei Xiao BDF , Zhouming Deng AC , Lin Cai AG , Yuanlong Xie ACDEF*DOI: 10.12659/MSM.928617
Med Sci Monit 2021; 27:e928617
Figure 1 Characterization of demineralized bone matrix-alginate (ADBM) composites. (A) The appearance of the prepared composites gel with various DBM/alginate amounts in hydrogel and dried status: 100 mg/1 mL, 50 mg/1 mL, 25 mg/1 mL, and alginate only (0 mg/1 mL). (B) Scanning electron microscope (SEM) images of the ADBM composites with various DBM/alginate amounts: alginate only (0 mg/1 mL), 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL; cross-sectional morphology as shown in Figure 1B. Scale bar: 100 μm. (C, D) In vitro degradation of ADBM composites in collagenase (C) and phosphate-buffered saline (D); n=3; * compared with the alginate; P<0.05. (E) The swelling ratio of ADBM composites. (F) The compressive modulus of ADBM composites. All error bars represent the mean±SEM for n=3, P<0.05.