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05 March 2021: Database Analysis

Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis

Zhengqing Yang BE , Hui Cheng CD , Yazhou Zhang F , Yan Zhou AG*

DOI: 10.12659/MSM.928523

Med Sci Monit 2021; 27:e928523

Figure 3 Identification of prognostic genes in the GSE76021 cohort. (A) Cluster dendrogram of samples in the GSE76021 cohort. The dendrogram branches represent the clustered samples. (B) Soft-threshold power analysis of the scale-free fit index (upper) and the mean connectivity (lower). (C) Dendrogram of gene clustering and module assignment. Modules are represented by different colors. (D) Heatmap of adjacencies in the eigengene network. Higher adjacency is represented by red color. (E) Interaction of co-expressing modules. Higher connectivity is represented by light color. (F) Heatmap of the correlation between module eigengenes and patients’ survival. Close relationships are represented by red color. (G) Volcano plot of DEGs between long-term survivors and short-term survivors in the GSE76021 cohort. (H) Venn diagram of the intersection between DEGs, prognostic genes according to Cox analysis, and the WGCNA-plum3 module. WGCNA – weighted correlation network analysis; DEGs – differentially expressed genes.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750