05 March 2021>: Database Analysis
Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic AnalysisZhengqing Yang BE , Hui Cheng CD , Yazhou Zhang F , Yan Zhou AG*
Med Sci Monit 2021; 27:e928523
Figure 2 Identification of prognostic genes in the TCGA-ACC cohort by WGCNA. (A) Cluster dendrogram of samples in the TCGA-ACC cohort to detect outliers. The dendrogram branches represent the clustered samples. (B) Soft-threshold power analysis of the scale-free fit index (upper) and the mean connectivity (lower). (C) Dendrogram of gene clustering and module assignment. Modules are represented by different colors. (D) Heatmap of adjacencies in the eigengene network. Higher adjacency is represented by red color. (E) Interaction of co-expressing modules. Higher connectivity is represented by light color. (F) Heatmap of the correlation between module eigengenes and patients’ survival. Close relationships are represented by red color. (G) Volcano plot of DEGs between long-term survivors and short-term survivors in the TCGA-ACC cohort. (H) Venn diagram of the intersection of DEGs between long-term survivors and short-term survivors, prognostic genes according to univariate Cox regression model, and the WGCNA-skyblue2 module. WGCNA – weighted correlation network analysis; DEGs – differentially expressed genes.