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09 March 2021: Lab/In Vitro Research

Effects of Pretreatment with Using 16S Ribosomal RNA Gene Sequencing in a Mouse Model of Acute Colitis Induced by Dextran Sulfate Sodium

Yi-jie Weng 1BCDEF* , Dan-xian Jiang 2BCDEF* , Jian Liang 1BCDF , Shi-cai Ye 1BCD , Wen-kai Tan 1BCF , Cai-yuan Yu 1BCF , Yu Zhou 1ACDEFG*

DOI: 10.12659/MSM.928478

Med Sci Monit 2021; 27:e928478

Figure 5 Changes in the microbial communities in the pretreated group. (A) The top 10 most frequently observed bacterial phyla in the communities. (B) The Shannon diversity index was higher in mice that received Bifidobacterium bifidum supplements for 3 weeks than in mice assessed on the day of sacrifice. The principal coordinate analysis (C) and unweighted pair group method with arithmetic mean tree (D) showed that the microbiota was initially clustered by different time points and treatments. Different features in the control and B. bifidum-pretreated groups on the day of sacrifice were identified using linear discriminate analysis effect size, with a local-density approximation value of 4.0 (E, F).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750