09 March 2021>: Lab/In Vitro Research
Effects of Pretreatment with Using 16S Ribosomal RNA Gene Sequencing in a Mouse Model of Acute Colitis Induced by Dextran Sulfate SodiumYi-jie Weng 1BCDEF* , Dan-xian Jiang 2BCDEF* , Jian Liang 1BCDF , Shi-cai Ye 1BCD , Wen-kai Tan 1BCF , Cai-yuan Yu 1BCF , Yu Zhou 1ACDEFG*
Med Sci Monit 2021; 27:e928478
Figure 3 Colon length and histopathology analysis for effect of Bifidobacterium bifidum colonization on dextran sulfate sodium-induced colon damage. (A) Average colon length was shorter in the control groups than those in the treated groups, but the difference was not significant. (B) Histologic scores were significantly lower in the mice pretreated with B. bifidum for 5 weeks (* P<0.05). (C–F) Inflammation was more serious in the control groups than in the B. bifidum-treated and -pretreated groups. The control groups exhibited inflammatory cell infiltration, moderate to severe erosion of the lamina propria mucosa, and even ulcerative damage (hematoxylin and eosin staining, magnification ×100).