29 May 2021>: Lab/In Vitro Research
Silencing Ribosomal Protein L22 Promotes Proliferation and Migration, and Inhibits Apoptosis of Gastric Cancer Cells by Regulating the Murine Double Minute 2-Protein 53 (MDM2-p53) Signaling PathwayZhenqing Sun 1ABCE* , Zhigang Qiu 1ABCE* , Zhengkun Wang 1DE , Honghui Chi 2DE , Peipei Shan 3CE*
Med Sci Monit 2021; 27:e928375
Figure 4 Silencing the ribosomal protein L22 (RPL22) activates MDM2-p53 signaling. (A) The expression of MDM2-p53 signaling-related proteins (MDM2 and p53) in MGC-803 cells was detected by a western blot. (B) The expression of MDM2-p53 signaling-related proteins (MDM2 and p53) in MKN45 cells was detected by a western blot. BLANK – cells without transfection; pcDNA-NC – cells transfected with pcDNA negative control; pcDNA-RPL22 – cells transfected with pcDNA-RPL22 plasmid; si-NC – cells transfected with siRNA negative control; si-RPL22-1 – cells transfected with siRNA-RPL22-1. (A, B) ** P<0.01 vs BLANK; ## P<0.01 vs BLANK.