29 May 2021: Lab/In Vitro Research
Silencing Ribosomal Protein L22 Promotes Proliferation and Migration, and Inhibits Apoptosis of Gastric Cancer Cells by Regulating the Murine Double Minute 2-Protein 53 (MDM2-p53) Signaling Pathway
Zhenqing Sun 1ABCE* , Zhigang Qiu 1ABCE* , Zhengkun Wang 1DE , Honghui Chi 2DE , Peipei Shan 3CE*DOI: 10.12659/MSM.928375
Med Sci Monit 2021; 27:e928375
Figure 1 Ribosomal protein L22 (RPL22) is downregulated in gastric cancer tissues and cell lines. (A) The mRNA expression of RPL22 in gastric cancer tissues and normal tissues was detected by a quantitative real-time-polymerase chain reaction. (B) The mRNA expression of RPL22 in gastric cancer cell lines (AGS, MKN-45, and MGC-803) and the normal human gastric epithelial cell line (GES-1) was detected by a quantitative real-time-polymerase chain reaction. (C) The protein expression of RPL22 in gastric cancer cell lines and the normal human gastric epithelial cell line (GES-1) was detected by a western blot. (A) *** P<0.001 vs normal tissues; (B, C) * P<0.05, ** P<0.01, *** P<0.001 vs GES-1.