04 January 2021: Animal Study
Effect of Parecoxib Sodium on Myocardial Ischemia-Reperfusion Injury Rats
Fangyong Wu 1AEG* , Wei Wang 2ABD , Yingying Duan 1BCF , Jia Guo 1CD , Guanhua Li 2BF , Tao Ma 2DFDOI: 10.12659/MSM.928205
Med Sci Monit 2021; 27:e928205
Figure 5 Effects of parecoxib sodium on activity of NF-κB and Nrf-2 signaling pathways. (A, B) Relative expressions of NF-κB and Nrf-2 pathways and target genes detected via PCR. The relative expressions of NF-κB pathway and its target genes were higher in the I/R group than those in the Sham group and I/R+Pare group (P<0.05). The relative expressions of Nrf-2 pathway and its target genes were lower in the I/R group than those in the Sham group and I/R+Pare group (P<0.01). (* P<0.05 vs. I/R group, ** P<0.01 vs. I/R group).