Figure 8 Protein expressions of drug efflux transporters, MRP, LRP, BCRP, Bcl-2, and PKC-α in tumor tissues. The protein expressions were detected using western blotting, and β-actin was used as the internal control. Compared with the model group, & P<0.05, && P<0.01; compared with the DOX group, # P<0.05, ## P<0.01; compared with the vector-nano group, * P<0.05, ** P<0.01. BCRP – breast cancer resistance protein; Bcl-2 – B-cell lymphoma 2; LRP – lung resistance protein; MRP – multidrug resistance protein; PKC-α – protein kinase C alpha.