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23 October 2020: Animal Study

Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (NEAT1) Represses Proliferation of Trophoblast Cells in Rats with Preeclampsia via the MicroRNA-373/FLT1 Axis

Lingling Teng 1ABEF* , Pingping Liu 2ABDE* , Xiao Song 3BCE , Hui Wang 4CEF , Jing Sun 5BDE , Zhongxia Yin 6CDEF*

DOI: 10.12659/MSM.927305

Med Sci Monit 2020; 26:e927305

Figure 5 NEAT1 modulates FLT1 via miR-373. (A) RT-qPCR measurements of FLT1 mRNA expression in cells transfected with siRNA-NEAT1 alone or in the presence of miR-373 inhibitor (* p<0.05 by 1-way ANOVA); (B) RT-qPCR measurements of FLT1 mRNA expression in cells transfected with pcDNA-NEAT1 with or without siRNA-FLT1 (* p<0.05 by 1-way ANOVA); (C) cell proliferation activity, measured by the CCK-8 method (* p<0.05 by 2-way ANOVA) and colony formation assay (* p<0.05 by 1-way ANOVA); (D) cell invasion and migration activities, measured by Transwell assays (* p<0.05 by 1-way ANOVA); (E) cell apoptosis, measured by flow cytometry (* p<0.05 by 1-way ANOVA). Each figure represents the average of 3 replicates.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750