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23 October 2020: Animal Study

Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (NEAT1) Represses Proliferation of Trophoblast Cells in Rats with Preeclampsia via the MicroRNA-373/FLT1 Axis

Lingling Teng 1ABEF* , Pingping Liu 2ABDE* , Xiao Song 3BCE , Hui Wang 4CEF , Jing Sun 5BDE , Zhongxia Yin 6CDEF*

DOI: 10.12659/MSM.927305

Med Sci Monit 2020; 26:e927305

Figure 4 miR-373 directly targets FLT1. (A) Binding sites between miR-373 and FLT1; (B) FLT1 mRNA expression in placentas of PE and control rats evaluated by RT-qPCR (** p<0.01 by unpaired t test); (C) relative luciferase activity in cells co-transfected with miR-373 mimic or miR-373 inhibitor and FLT1-WT-3′UTR or FLT1-MT-3′UTR (* p<0.05 by 2-way ANOVA); (D) FLT1 mRNA expression measured in cells transfected with miR-373 mimic or inhibitor by RT-qPCR (* p<0.05 by 1-way ANOVA). Each figure represents the average of 3 replicates.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750