Therapeutic Effect of an Anti-Human Programmed Death-Ligand 1 (PD-L1) Nanobody on Polymicrobial Sepsis in Humanized Mice

Zhen-zhen Zhao; Xiao-lin Wang; Jian Xie; Li-ping Chen; Qian Li; Xiao-xiao Wang; Jia-feng Wang; Xiao-ming Deng

doi:10.12659/MSM.926820

09 January 2021: Animal Study

Therapeutic Effect of an Anti-Human Programmed Death-Ligand 1 (PD-L1) Nanobody on Polymicrobial Sepsis in Humanized Mice

Zhen-zhen Zhao ^1ABCDG* , Xiao-lin Wang ^1ABCD* , Jian Xie ^1ABCDF* , Li-ping Chen ^2B , Qian Li ^2B , Xiao-xiao Wang ^2B , Jia-feng Wang ^1ACDEFG* , Xiao-ming Deng ^1ACDEFG*

DOI: 10.12659/MSM.926820

Med Sci Monit 2021; 27:e926820

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Figure 3 KN035 improved the survival rate in cecal ligation and puncture (CLP) mice. N=10 per group. * P=0.0083 vs. CLP group and isotype group. CLP – cecal ligation and puncture.

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Therapeutic Effect of an Anti-Human Programmed Death-Ligand 1 (PD-L1) Nanobody on Polymicrobial Sepsis in Humanized Mice

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