09 January 2021>: Animal Study
Therapeutic Effect of an Anti-Human Programmed Death-Ligand 1 (PD-L1) Nanobody on Polymicrobial Sepsis in Humanized Mice
Zhen-zhen Zhao 1ABCDG* , Xiao-lin Wang 1ABCD* , Jian Xie 1ABCDF* , Li-ping Chen 2B , Qian Li 2B , Xiao-xiao Wang 2B , Jia-feng Wang 1ACDEFG* , Xiao-ming Deng 1ACDEFG*DOI: 10.12659/MSM.926820
Med Sci Monit 2021; 27:e926820
Figure 1 Anti-programmed death-ligand 1 (PD-L1) expression is upregulated in peripheral lymphocytes, monocytes, and neutrophils from septic mice with PD-L1 humanization at 24 h after cecal ligation and puncture (CLP) surgery. Data shown as mean±standard deviation (SD) (n=6 per group). P<0.05 vs. sham group. CLP – cecal ligation and puncture.