20 October 2020: Lab/In Vitro Research
Verteporfin Promotes the Apoptosis and Inhibits the Proliferation, Migration, and Invasion of Cervical Cancer Cells by Downregulating SULT2B1 Expression
Lijun Yin 1BCDEF , Guilin Chen 2AF*DOI: 10.12659/MSM.926780
Med Sci Monit 2020; 26:e926780
Figure 6 SULT2B1 overexpression weakened the inhibiting effect of verteporfin (VP) on the migration and invasion of cervical cancer cells. (A, B) The migration of HeLa cells after transfection and VP treatment was analyzed by wound healing assay. ** P<0.01 and *** P<0.001 vs. Control group. # P<0.05 vs. VP group. @ P<0.05 vs. OE-NC group. (C, D) The migration of HeLa cells after transfection and VP treatment was analyzed by transwell assay. * P<0.05 and *** P<0.001 vs. Control group. ### P<0.001 vs. VP group. @@@ P<0.001 vs. OE-NC group. (E) The expression of MMP2 and MMP9 in HeLa cells after transfection and VP treatment was determined by western blot analysis. * P<0.05, ** P<0.01 and *** P<0.001 vs. Control group. ## P<0.01 and ### P<0.001 vs. VP group. @@ P<0.01 and @@@ P<0.001 vs. OE-NC group.