18 November 2020: Animal Study
Reduced Amygdala Microglial Expression of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B (TrkB) in a Rat Model of Poststroke Depression
Han-xiao Zhu 1ACE* , Li-jing Cheng 1ABCE* , Ri-wei Ou Yang 1CD , Yang-yang Li 1CDF , Jian Liu 1BCD , Dan Dai 1DF , Wei Wang 1BF , Ning Yang 1BDF , Yun Li 2AG*DOI: 10.12659/MSM.926323
Med Sci Monit 2020; 26:e926323
Figure 3 Dual-immunofluorescence detection of BDNF or TrkB expression by amygdala microglia 4 weeks after CUMS. (A) BDNF or TrkB expression (red fluorescence) in CD11b-positive microglia (green fluorescence, merged yellow fluorescence) (bar=20 μm). (B) Histograms show the number of BDNF/CD11b- or TrkB/CD11b-positive cells in amygdala microglia of each group. N=5 rats/group. * P<0.05 versus normal control rats; @ P<0.05 versus depression model rats; # P<0.05 versus stroke model rats. BDNF – brain-derived neurotrophic factor; CUMS – chronic unpredictable mild stress; TrkB – tyrosine kinase receptor B.