18 November 2020: Animal Study
Reduced Amygdala Microglial Expression of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B (TrkB) in a Rat Model of Poststroke Depression
Han-xiao Zhu 1ACE* , Li-jing Cheng 1ABCE* , Ri-wei Ou Yang 1CD , Yang-yang Li 1CDF , Jian Liu 1BCD , Dan Dai 1DF , Wei Wang 1BF , Ning Yang 1BDF , Yun Li 2AG*DOI: 10.12659/MSM.926323
Med Sci Monit 2020; 26:e926323
Figure 2 Effects of t-PA, proBDNF, or NS administered by ICV injection on depression-like behavior in PSD models rats. Histograms show (A) body weight (feeding behavior), (B) sucrose preference, (C) rearing activity, and (D) locomotor activity in rats injected with NS, t-PA, or proBDNF as indicated. N=8 rats/group. * P<0.05 versus NS-treated rats; # P<0.05 versus t-PA-treated rats. BDNF – brain-derived neurotrophic factor; ICV – intracerebroventricular; NS – normal saline; PSD – poststroke depression; t-PA – tissue plasminogen activator.