18 November 2020: Animal Study
Reduced Amygdala Microglial Expression of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B (TrkB) in a Rat Model of Poststroke Depression
Han-xiao Zhu 1ACE* , Li-jing Cheng 1ABCE* , Ri-wei Ou Yang 1CD , Yang-yang Li 1CDF , Jian Liu 1BCD , Dan Dai 1DF , Wei Wang 1BF , Ning Yang 1BDF , Yun Li 2AG*DOI: 10.12659/MSM.926323
Med Sci Monit 2020; 26:e926323
Figure 1 Behavioral testing results in each group at different time points after CUMS. Histograms show (A) body weight (indicative of feeding behavior), (B) sucrose preference, (C) rearing activity, and (D) locomotor activity. Data are presented as mean±SE. Intergroup comparisons evaluated by 1-way ANOVA. N=10 rats/group; 1 (first day after CUMS), 2 (2 weeks), 3 (4 weeks), 4 (8 weeks). * P<0.05 versus normal control rats; @ P<0.05 versus depression model rats (isolation-housing combined with CUMS); # P<0.05 versus stroke model rats (MCAO only). ANOVA – analysis of variance; CUMS – chronic unpredictable mild stress; MCAO – middle cerebral artery occlusion.