The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways

Jialu Zhou; Fan Zhang; Hongru Lin; Minxue Quan; Yaqin Yang; Yanni Lv; Zongnan He; Yisong Qian

doi:10.12659/MSM.926254

05 October 2020: Animal Study

The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways

Jialu Zhou ^1B* , Fan Zhang ^2B* , Hongru Lin ^1B , Minxue Quan ^1B , Yaqin Yang ^1B , Yanni Lv ^3C , Zongnan He ^4CE* , Yisong Qian ^1ACE*

DOI: 10.12659/MSM.926254

Med Sci Monit 2020; 26:e926254

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Figure 4 C16 suppresses the renal protein kinase R (PKR)/eIF2α signaling pathway. (A) Immunoblots of phospho-PKR (pPKR), total PKR (PKR), phospho-eIF2α (peIF2α), total eIF2α (eIF2α), and glyceraldehyde-3-phosphate dehydrogenase. The levels of (B) pPKR and (C) peIF2α were quantitatively analyzed and are shown as mean±standard deviation (n=8). **P<0.01.

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The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways

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