05 October 2020: Animal Study
The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways
Jialu Zhou 1B* , Fan Zhang 2B* , Hongru Lin 1B , Minxue Quan 1B , Yaqin Yang 1B , Yanni Lv 3C , Zongnan He 4CE* , Yisong Qian 1ACE*DOI: 10.12659/MSM.926254
Med Sci Monit 2020; 26:e926254
Figure 2 C16 inhibits renal inflammatory responses after lipopolysaccharide (LPS) injection. Real-time polymerase chain reaction was used to measure renal levels of proinflammatory cytokines and chemokines after LPS injection. (A) Tumor necrosis factor α. (B) Interleukin (IL)-1β. (C) IL-6. (D) Monocyte chemoattractant protein-1. (E) inducible nitric oxide synthase. (F) Cyclooxygenase-2. Data are presented as mean±standard deviation (n=6). * P<0.05, ** P<0.01.