18 November 2020: Animal Study
Altered Inflammatory Pathway but Unaffected Liver Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis Involving Interleukin-1 Receptor-Associated Kinase 1 Knockout
Ying Lei BCDE* , Tianxiao Yang BEFG* , Aijing Shan CDG , Wei Di BC , Mengyao Dai EFG , Jingminjie Nan B , Dongxue Liu B , Yanan Cao AEG , Xiuli Jiang AEG*DOI: 10.12659/MSM.926187
Med Sci Monit 2020; 26:e926187
Figure 1 Generation of Irak1 KO mice. (A) Schematic representation of the generation of Irak1 KO mice. (B) Levels of Irak1 mRNA in various tissues of Irak1 KO and control mice (n=6 each). (C) Levels of IRAK1 protein in the livers of Irak1 KO and control mice (n=5 each). (D) Hepatic levels of Tnfα, Il1β, Il6, Tgfb1, and Adgre1 mRNAs in Irak1 KO and control mice (n=6 each). (E) Hepatic levels of Irak1, Irak2, Irak3, Irak4, Traf6, Ikkα, Ikkβ, and p65 mRNAs in Irak1 KO and control mice (n=6 each). Data represent mean±SEM. * p<0.05, ** p<0.01, *** p< 0.001, by t tests.