30 September 2020>: Animal Study
Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber
Huan Yu 1BCE* , Huimin Zhong 2CDF* , Junjue Chen 1DF , Jun Sun 1BF , Ping Huang 3EF , Xing Xu 3CE , Shouyue Huang 1ADE , Yisheng Zhong 1AG*DOI: 10.12659/MSM.925852
Med Sci Monit 2020; 26:e925852
Figure 4 Histomorphological and apoptotic changes of cornea, iris, ciliary body, and anterior chamber induced by chronic ocular hypertension (COH). (A–D) The frozen sections and TUNEL staining of the anterior segment (A–C represent cornea, iris, and ciliary body, respectively; magnification 200, scale bar=100 μm; (D) Anterior chamber angle, magnification 100, scale bar=100 μm). (E) There was no significant difference in the number of TUNEL-positive corneal endothelial cells (CECs) in the corneas at 2 and 4 weeks after ocular hypertension compared with that of the control group (n=6, P=0.503, 0.207, respectively). At 8 weeks after ocular hypertension, the number of CECs positive for TUNEL staining increased in a single field of view compared with the control group.