Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber

Huan Yu; Huimin Zhong; Junjue Chen; Jun Sun; Ping Huang; Xing Xu; Shouyue Huang; Yisheng Zhong

doi:10.12659/MSM.925852

30 September 2020: Animal Study

Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber

Huan Yu ^1BCE* , Huimin Zhong ^2CDF* , Junjue Chen ^1DF , Jun Sun ^1BF , Ping Huang ^3EF , Xing Xu ^3CE , Shouyue Huang ^1ADE , Yisheng Zhong ^1AG*

DOI: 10.12659/MSM.925852

Med Sci Monit 2020; 26:e925852

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Figure 3 Intraocular pressure (IOP) changes of the rats administered continuously for 1 week. IOP of rats treated with brimonidine, timolol, and bimatoprost were significantly lower than in the control group at 2–7 days after administration, and the difference was statistically significant (P<0.05). The IOP of the rats treated with brinzolamide and pilocarpine were not significantly different from the control group at 2–7 days after administration (P>0.05).

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Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber

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