30 September 2020: Animal Study
Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber
Huan Yu 1BCE* , Huimin Zhong 2CDF* , Junjue Chen 1DF , Jun Sun 1BF , Ping Huang 3EF , Xing Xu 3CE , Shouyue Huang 1ADE , Yisheng Zhong 1AG*DOI: 10.12659/MSM.925852
Med Sci Monit 2020; 26:e925852
Figure 1 Changes of latency and amplitude of P1 induced by chronic ocular hypertension (COH) in Flash Visual evoked potentials (F-VEP) test. (A) F-VEP detection waveforms of rats at 0, 2, 4, and 8 weeks of COH. (B) The latency of the P1 increases along in accordance with the prolongation of COH. The latencies of 4 and 8 weeks after COH were significantly longer than that of the control group (n=28; * P<0.05 versus the control group, # P<0.05 versus the COH 2 weeks group, & P<0.05 versus the COH 4 weeks group); (C) The amplitude of P1 decreased along with the prolongation of COH. The amplitudes at 2, 4, and 8 weeks after COH were significantly lower than that of the control group (n=28; * P<0.05 versus the control group, # P<0.05 versus the COH 2 weeks group, & P<0.05 versus the COH 4 weeks group).