miR-22-3p Suppresses Endothelial Progenitor Cell Proliferation and Migration via Inhibiting Onecut 1 (OC1)/Vascular Endothelial Growth Factor A (VEGFA) Signaling Pathway and Its Clinical Significance in Venous Thrombosis

Huoqi Liang; Yibiao Chen; Hefei Li; Xiaoqiang Yu; Chunqiu Xia; Zhibing Ming; Chongjun Zhong

doi:10.12659/MSM.925482

02 September 2020: Clinical Research

miR-22-3p Suppresses Endothelial Progenitor Cell Proliferation and Migration via Inhibiting Onecut 1 (OC1)/Vascular Endothelial Growth Factor A (VEGFA) Signaling Pathway and Its Clinical Significance in Venous Thrombosis

Huoqi Liang ^ABDE* , Yibiao Chen ^BCDF* , Hefei Li ^CDF , Xiaoqiang Yu ^CEF , Chunqiu Xia ^CF , Zhibing Ming ^AEG* , Chongjun Zhong ^AFG*

DOI: 10.12659/MSM.925482

Med Sci Monit 2020; 26:e925482

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Figure 3 Onecut 1 (OC1) is negatively regulated by miR-22-3p. (A) Bioinformatic analysis predicted the 3′-untranslated region (UTR) of OC1 with the potential binding sites of miR-22-3p. (B) Luciferase report assay showed the activity in different groups. (C) Western blot analysis revealed the protein expression of OC1. ** P<0.01.

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miR-22-3p Suppresses Endothelial Progenitor Cell Proliferation and Migration via Inhibiting Onecut 1 (OC1)/Vascular Endothelial Growth Factor A (VEGFA) Signaling Pathway and Its Clinical Significance in Venous Thrombosis

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