Figure 6 Detection of hub genes. (A) A Venn diagram presenting hub genes under coexpression and those involved in the PPI network. (B) Ten hub genes (COL3A1, POSTN, COL6A3, COL14A1, SERPINH1, ASPN, OGN, THY1, NID2, and TNMD) overlapped between the PPI and the coexpression networks. In the heat map, intensity and color of hub genes are shown at right, which represent the gene rank 1 to 10. PPI, protein-protein interaction; COL3A1 – collagen type III alpha 1 chain; POSTN – periostin; COL6A3 – collagen type VI alpha 3 chain; COL14A1 – collagen type XIV alpha 1 chain; SERPINH1 – serpin family H member 1; ASPN – asporin; OGN – osteoglycin; THY1 – Thy-1 cell surface antigen; NID2 – nidogen 2; TNMD – tenomodulin.