07 August 2020>: Lab/In Vitro Research
Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer
Ji-Min Li 1ABCE* , Fang Yang 1C* , Juan Li 2C , Wei-Qi Yuan 1D , Hao Wang 1BG , Yi-Qin Luo 1DG*DOI: 10.12659/MSM.925298
Med Sci Monit 2020; 26:e925298
Figure 3 Reelin promotes EMT in NSCLC cells. (A) Cell morphological observations after Reelin overexpression (A549-NC versus A549/Reelin) in A549 cells and Reelin knockdown in A549/DDP cells (A549/DDP si-NC versus A549/DDP si-Reelin). (B–D) E-cadherin and N-cadherin expressions were evaluated by western blotting and immunofluorescence in A549 cells transfected with the Reelin expression vector and A549/DDP cells transfected with Reelin si-RNA. (E, F) Cell migration was measured by Transwell migration assays. * P<0.05, ** P<0.01.