Figure 3 Z-LIG protects the morphometric structure of the retina in diabetic rats after 12 weeks of treatment. (A) Typical HE staining image of the retina. (B) Thickness of retinal INL+OPL+ONL. (C) Thickness of the retinal ILM. GCL – ganglion cell layer; ILM – internal limiting membrane; INL – inner nuclear layer; IPL – inner plexiform layer; IS/OS – photoreceptor inner segment/outer segment; ONL – outer nuclear layer; OPL – outer plexiform layer. Values are presented as mean±standard deviation, n=4. * P<.05, *** P<.001: DM group, DM+Z-LIG group vs. control group; ### P<.001: DM+Z-LIG group vs. DM group.