Positive Cross-Talk Between CXC Chemokine Receptor 4 (CXCR4) and Epidermal Growth Factor Receptor (EGFR) Promotes Gastric Cancer Metastasis via the Nuclear Factor kappa B
(NF-kB)-Dependent Pathway

Yu Cheng; Xiaofang Che; Simeng Zhang; Tianshu Guo; Xin He; Yunpeng Liu; Xiujuan Qu

doi:10.12659/MSM.925019

03 September 2020: Clinical Research

Positive Cross-Talk Between CXC Chemokine Receptor 4 (CXCR4) and Epidermal Growth Factor Receptor (EGFR) Promotes Gastric Cancer Metastasis via the Nuclear Factor kappa B (NF-κB)-Dependent Pathway

Yu Cheng ^123ABCDEG , Xiaofang Che ^123A , Simeng Zhang ^123C , Tianshu Guo ^123F , Xin He ^123F , Yunpeng Liu ^123AG* , Xiujuan Qu ^123AG*

DOI: 10.12659/MSM.925019

Med Sci Monit 2020; 26:e925019

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Figure 6 A working model for amplified cross-talk between CXCR4 and EGFR to promote gastric cancer metastasis. A positive feedback loop of CXCR4/EGFR-NF-κB-CXCR4/EGFR exists in the gastric cancer signaling network, which ultimately increases gastric cancer cellular metastasis.

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Positive Cross-Talk Between CXC Chemokine Receptor 4 (CXCR4) and Epidermal Growth Factor Receptor (EGFR) Promotes Gastric Cancer Metastasis via the Nuclear Factor kappa B (NF-κB)-Dependent Pathway

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