03 August 2020: Animal Study
Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-κB) Pathway Downregulation
Ziqiang Cui 1BCDE , Yaping Lin 2BCD , Yuhong Liu 3BCEF , Ling Cao 3BDE , Li Cui 3ACDEF*DOI: 10.12659/MSM.924787
Med Sci Monit 2020; 26:e924787
Figure 5 Effect of RT-Pt(II) on MEK/NF-κB phosphorylation. The RT-Pt(II) exposed cells at 4 to 12 μM were treated with TNF-α at 48 h of exposure. (A) The measurement of phosphorylation for MEK/NF-κB (p-665) was performed by western blotting at 72 h of RT-Pt(II) treatment. (B) Semi-quantification of the data * P<0.02 and ** P<0.01 vs. TNF-α treated cells.