03 August 2020>: Animal Study
Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-κB) Pathway Downregulation
Ziqiang Cui 1BCDE , Yaping Lin 2BCD , Yuhong Liu 3BCEF , Ling Cao 3BDE , Li Cui 3ACDEF*DOI: 10.12659/MSM.924787
Med Sci Monit 2020; 26:e924787
Figure 4 Effect of RT-Pt(II) on iNOS/COX-2 in TNF-α exposed cells. The RT-Pt(II) treated cells at 4 and 12 μM concentrations for 48 h were exposed to TNF-α. (A) The protein levels were measured at 72 h of RT-Pt(II) treatment by western blotting. (B) In RT-Pt(II) treated cells mRNA levels were analyzed at 72 h using RT-PCR. * P<0.02 and ** P<0.01 vs. TNF-α treated cells.