28 June 2020>: Lab/In Vitro Research
Meteorin-Like (METRNL) Attenuates Myocardial Ischemia/Reperfusion Injury-Induced Cardiomyocytes Apoptosis by Alleviating Endoplasmic Reticulum Stress via Activation of AMPK-PAK2 Signaling in H9C2 Cells
Ling Xu A , Yinlian Cai CD , Yaoguo Wang B , Chaoxiang Xu C**DOI: 10.12659/MSM.924564
Med Sci Monit 2020; 26:e924564
Figure 3 METRNL overexpression inhibited ER stress and promoted the PAK2 expression. (A, B) The expressions of GRP78, ATF4, ATF6, CHOP, and PAK2 were determined by western blot. Error bars represent the mean±SEM from 3 independent experiments. *** P<0.001 versus Control; ## P<0.01, ### P<0.001 versus OGD/R 12 hours. METRNL – Meteorin-like; ER – endoplasmic reticulum; PAK2 – p21-activated kinase 2; GRP78 – glucose-regulated protein 78; ATF – activating transcription factor; CHOP – C/EBP-homologus protein; SEM – standard error of the mean; OGD/R – oxygen-glucose deprivation and reperfusion.