13 September 2020: Animal Study
AEB-071 Ameliorates Muscle Weakness by Altering Helper T Lymphocytes in an Experimental Autoimmune Myasthenia Gravis Rat Model
Feng Jing 1AE , Wei Huang 1BC , Qian Ma 1BC , Sheng-jie Xu 1BC , Chang-jin Wu 2BC , Yu-xiu Guan 2BC , Bing Chen 1A*DOI: 10.12659/MSM.924393
Med Sci Monit 2020; 26:e924393
Figure 2 AEB-071 improved the clinical symptom of EAMG rats. (A) AEB-071 treatment reversed the body weight decline in EAMG rats. (B) AEB-071 treatment reduced the Lennon score in EAMG rats. (C) AEB-071 treatment reduced serum anti-AChR level in EAMG rats as measured by ELISA analysis after 10 days of drug intervention. The results are expressed as mean±SD (n=5 rats/group). * P<0.05 compared to control group; # P<0.05 compared to EAMG group; & P<0.05 compared to AEB-071+EAMG group.