22 July 2020>: Clinical Research
Phospholipase Cɛ Regulates Prostate Cancer Lipid Metabolism and Proliferation by Targeting AMP-Activated Protein Kinase (AMPK)/Sterol Regulatory Element-Binding Protein 1 (SREBP-1) Signaling Pathway
Yongbo Zheng 1ABCDEF* , Jiajia Jin 2ABCDF* , Yingying Gao 3ACF , Chunli Luo 4AG , Xiaohou Wu 1AG* , Jiayu Liu 1ABCDE*DOI: 10.12659/MSM.924328
Med Sci Monit 2020; 26:e924328
Figure 7 Silencing PLCɛ suppresses lipid metabolism and proliferation of PC3 cells in vivo. (A) Immunohistochemical assays were used to detect the expression of PLCɛ, p-AMPK, SREBP-1, and Ki67 in silenced PLCɛ and NC group (200×,100 μm bar) (a–j). (B–D) Tumor size, weight, and dynamic volume were measured. (E) Ki67 was quantified in NC and knockdown PLCɛ groups. *** p<0.001, ns – no statistical significance; NC – negative bontrol.