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22 July 2020: Clinical Research

Phospholipase Cɛ Regulates Prostate Cancer Lipid Metabolism and Proliferation by Targeting AMP-Activated Protein Kinase (AMPK)/Sterol Regulatory Element-Binding Protein 1 (SREBP-1) Signaling Pathway

Yongbo Zheng 1ABCDEF* , Jiajia Jin 2ABCDF* , Yingying Gao 3ACF , Chunli Luo 4AG , Xiaohou Wu 1AG* , Jiayu Liu 1ABCDE*

DOI: 10.12659/MSM.924328

Med Sci Monit 2020; 26:e924328

Figure 5 Silencing PLCɛ blocks SREBP-1 nuclear translocation. (A) Immunofluorescence staining revealed SREBP-1 intracellular distribution changes in LNCap and PC3 cells. (B–E) Western blot illustrated that silencing PLCɛ observably downregulates SREBP-1 expression in the nucleus but not in the cytoplasm in the 2 PCa cell lines.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750