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22 July 2020: Clinical Research

Phospholipase Cɛ Regulates Prostate Cancer Lipid Metabolism and Proliferation by Targeting AMP-Activated Protein Kinase (AMPK)/Sterol Regulatory Element-Binding Protein 1 (SREBP-1) Signaling Pathway

Yongbo Zheng 1ABCDEF* , Jiajia Jin 2ABCDF* , Yingying Gao 3ACF , Chunli Luo 4AG , Xiaohou Wu 1AG* , Jiayu Liu 1ABCDE*

DOI: 10.12659/MSM.924328

Med Sci Monit 2020; 26:e924328

Figure 3 Silencing PLCɛ suppresses proliferation-related factors and fatty acid synthesis-related enzymes in PCa cell lines. (A–D) PC3 and LNCap cells treated with 3 types of lentivirus for knocking down PLCɛ, and the PLCɛ protein and mRNA levels were detected by Western blot and qPCR. (E–J) Knockdown of PLCɛ decreased the protein and mRNA levels of lipid metabolism-related enzymes and proliferation-related factors in PCa cells using Western blot and qPCR vs. NC.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750