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22 July 2020: Clinical Research

Phospholipase Cɛ Regulates Prostate Cancer Lipid Metabolism and Proliferation by Targeting AMP-Activated Protein Kinase (AMPK)/Sterol Regulatory Element-Binding Protein 1 (SREBP-1) Signaling Pathway

Yongbo Zheng 1ABCDEF* , Jiajia Jin 2ABCDF* , Yingying Gao 3ACF , Chunli Luo 4AG , Xiaohou Wu 1AG* , Jiayu Liu 1ABCDE*

DOI: 10.12659/MSM.924328

Med Sci Monit 2020; 26:e924328

Figure 2 PLCɛ and lipid metabolism are increased in PCa cells. (A–D) Lipid droplets content level of the PCa cells (LNCaP, PC3) and RWPE-1 cells were analyzed by Nile red staining and Oil red O staining (400×, 200 μm bar). (E–G) Western blot and qPCR were performed to test the protein and mRNA expression levels of SREBP-1, FASN, and PLCɛ. The intensity of protein was quantified by image J software. Data are shown as mean±SD. *** p<0.001, ** p<0.01.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750