22 July 2020: Clinical Research
Phospholipase Cɛ Regulates Prostate Cancer Lipid Metabolism and Proliferation by Targeting AMP-Activated Protein Kinase (AMPK)/Sterol Regulatory Element-Binding Protein 1 (SREBP-1) Signaling Pathway
Yongbo Zheng 1ABCDEF* , Jiajia Jin 2ABCDF* , Yingying Gao 3ACF , Chunli Luo 4AG , Xiaohou Wu 1AG* , Jiayu Liu 1ABCDE*DOI: 10.12659/MSM.924328
Med Sci Monit 2020; 26:e924328
Figure 1 High expression of PLCɛ in PCa tissue specimens is related with SREBP-1/FASN. (A) Hematoxylin and eosin (HE) staining was performed on BPH and PCa tissue specimens, and PLCɛ, SREBP-1, and FASN expression levels were detected by immunohistochemistry (IHC) (200×, 100 μm bar) (a–h). (B–D) Staining scores for SREBP-1, FASN, and PLCɛ in BPH and PCa specimens. (E, F) The correlation between SREBP-1 and PLC and between FASN and PLCɛ in PCa tissue specimens was examined by Spearman analysis. (G). Progression-free survival in PCa patients was analyzed by Kaplan-Meier survival analysis.