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28 July 2020: Lab/In Vitro Research

CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer and Inhibits Tumorigenesis via the miR-452-5p/KAT6B Axis

Lingyu Zhu 1BCDE , Chunfei Wang 1CDEF , Shengquan Lin 2BCDE , Lei Zong 1ABCD*

DOI: 10.12659/MSM.924160

Med Sci Monit 2020; 26:e924160

Figure 7 CircKIAA0907 inhibited tumorigenesis of gastric cancer (GC) in vivo via the miR-452-5p/KAT6B axis. (A) Tumor volume was recorded weekly after injecting HGC27 and AGS cells transfected with circKIAA0907 or vector. (B, C) Tumors were weighed (B) after excision from mice (C). (D) Quantitative real-time polymerase chain reaction (qRT-PCR) was used for examining expression of circKIAA0907, miR-452-5p, and KAT6B mRNA. (E) KAT6B protein level detected using western blot. * P<0.05.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750