07 May 2020: Lab/In Vitro Research
Potential Molecular Mechanisms and Drugs for Aconitine-Induced Cardiotoxicity in Zebrafish through RNA Sequencing and Bioinformatics Analysis
Mingzhu Wang 1CDEF , Yanan Shi 1BDF , Lei Yao 1CDF , Qiang Li 2ACDFG , Youhua Wang 3ABDFG , Deyu Fu 1ABEFG*DOI: 10.12659/MSM.924092
Med Sci Monit 2020; 26:e924092
Figure 3 (A) Core PPI network and hub genes identified by CytoNCA and Cytoscape. More important nodes received higher quantitative values within the network. The list of the sequence of the top 20 genes. The shade of the color indicates the degree of the gene. (B) Screen hub therapeutic target gene. drug-gene interaction network (left) and core PPI network (right). (C) Key signal pathways. A network of KEGG-druggable genes (left) and top 20 KEGG items of DEGs (right). PPI – protein-protein interaction; KEGG – Kyoto Encyclopedia of Genes and Genomes; DEGs – differentially expressed genes.