20 July 2020>: Animal Study
Pyrazolo[4,3-c]pyridine-4-one (PP-4-one) Exhibits Anti-Epileptogenic Effect in Rat Model of Traumatic Epilepsy by Mammalian Target of Rapamycin (mTOR) Signaling Pathway Downregulation
Jungong Jin 1BCD , Xi Shen 2BCF , Lu Tian 3BCD , Guoyishi He 1BCD , Ying Zhang 3ADEF*DOI: 10.12659/MSM.923919
Med Sci Monit 2020; 26:e923919
Figure 7 Effect of PP-4-one on mTOR/P70S6K activation. (A, B) The PTE rats treated with or without PP-4-one treatment were assessed for mTOR/P70S6K phosphorylation in hippocampal and frontal lobe tissues by Western blot analysis. (C, D) Quantified data for mTOR/P70S6K phosphorylation in hippocampal and frontal lobe tissues. * P<0.02 and ** P<0.02 vs. vehicle-treated rats.