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09 July 2020: Lab/In Vitro Research

miR-512-3p Overcomes Resistance to Cisplatin in Retinoblastoma by Promoting Apoptosis Induced by Endoplasmic Reticulum Stress

Miao Kong 1BCDEF* , Yuanyuan Han 2BCDEF* , Yunhe Zhao 3DF , Hong Zhang 4AF*

DOI: 10.12659/MSM.923817

Med Sci Monit 2020; 26:e923817

Figure 5 miR-512-3p affects the related proteins expression in ERS. (A) The expression of GRP78, ATF4, ATF6 and IRE1 in Y79/DDP cells after transfection was determined by Western blot analysis. * P<0.05 and ** P<0.05 vs. Y79 group. # P<0.05, ## P<0.01 and ### P<0.001 vs. Y79/DDP group. && P<0.01 and &&& P<0.001 vs. Y79/DDP+mimic NC group. $$$ P<0.001 vs. Y79/DDP+inhibitor NC group. (B) The expression of CHOP, XBP-1s, XBP-1u and Casp-4 in Y79/DDP cells after transfection was determined by Western blot analysis. *** P<0.001 vs. Y79 group. # P<0.05 and ### P<0.001 vs. Y79/DDP group. & P<0.05 and &&& P<0.001 vs. Y79/DDP+mimic NC group. $ P<0.05 vs. Y79/DDP+inhibitor NC group.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750