29 June 2020: Animal Study
Kupffer Cells Regulate Natural Killer Cells Via the NK group 2, Member D (NKG2D)/Retinoic Acid Early Inducible-1 (RAE-1) Interaction and Cytokines in a Primary Biliary Cholangitis Mouse Model
Hai-Yan Fu 1EF , Wei-Min Bao 2C , Cai-Xia Yang 1D , Wei-Ju Lai 1D , Jia-Min Xu 1B , Hai-Yan Yu 1B , Yi-Na Yang 1B , Xu Tan 1B , Ajay Kumar Gupta 1F , Ying-Mei Tang 1AG*DOI: 10.12659/MSM.923726
Med Sci Monit 2020; 26:e923726
Figure 1 Changes during disease progression in a mouse model of PBC. (A) Changes in serum ALT and ALP in the PBC group and CON group at 2, 4, 6, and 8 weeks are expressed as the mean±SEM; n=5 for each group. (B) Changes in serum AMA-M2 and ANA in the PBC group and CON group at 2, 4, 6, and 8 weeks. Data are expressed as a count, n=5 for each group. (C) Changes in serum CD4+ and CD8+ T cell populations in the PBC and CON groups at 2, 4, 6, and 8 weeks. Data are expressed as the mean±SEM; n=5 for each group. (D) The livers of mice in the PBC and CON groups were collected at 2, 4, 6, and 8 weeks and stained with H&E (original magnification, 200×). PBC – primary biliary cholangitis; ALT – alanine transaminase; ALP – alkaline phosphatase; CON – control; SEM – standard error of the mean; AMA-M2 – anti-mitochondrial antibody M2; ANA – anti-nuclear antibody; H&E – hematoxylin & eosin.